Thiotepa( Purity > 99% by HPLC)

Product Name: Thiotepa
 CAT#: A-2231

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 Synonym: thiophosphamide; thiophosphoramide; triethylene thiophosphoramide. US brand names: Girostan; STEPA; TESPA; Thiofozil; Thioplex; Tifosyl. Foreign brand names: Ledertepa; Onco Tiotepa; Oncotiotepa; T ,

Thiotepa Chemical Structure
Thiotepachemical structure

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IUPAC/Chemical name:

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Biological Activity
Thiotepa is a polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth
Technical Data

Purity: >99%
Chemical Formula:C6H12N3PS
Molecular Weight:189.22
Thiotepa MSDSThiotepa CoA

IUPAC/Chemical name:tri(aziridin-1-yl)phosphine sulfide
Canonical SMILES:

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