Product Name: StreptozocinRequest Streptozocin
Synonym:Code name: U-9889; U9889; U 9889. Abbreviations: STZ; SZC; SZN; streptozotocin. US brand name: Zanosar. ,
Streptozocin Chemical Structure
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Biological ActivityStreptozocin is a methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression.
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