Product Name: Sorafenib (free base)Request Sorafenib (free base)
Synonym:BAY 43-9006; BAY43-9006; BAY439006; BAY 43-9006 Tosylate Salt; BAY 54-9085; US brand name: Nexavar; Abbreviation: SFN. ,
Sorafenib (free base) Chemical Structure
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Biological Activitysorafenib is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer.
IUPAC/Chemical name:4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide 4-methylbenzenesulfonate.
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