Maitansine (maytansine)( Purity > 99% by HPLC)

Product Name: Maitansine (maytansine)
 CAT#: A-2135

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 Synonym:NSC153858; NSC 153858; NSC-153858; maytansine; Maitansine; Maitansina; Maitansinum; DM-1; Mertansine. ,

Maitansine (maytansine) Chemical Structure
Maitansine (maytansine)chemical structure

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IUPAC/Chemical name:

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Biological Activity
Maitansine (INN), or maytansine (USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus. An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo.
Technical Data

Purity: >99%
Chemical Formula:C34H46ClN3O10
Molecular Weight:692.20
Maitansine (maytansine) MSDSMaitansine (maytansine) CoA

IUPAC/Chemical name: (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-acetyl-N-methyl-L-alaninate
Canonical SMILES:C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)C)C)\C)OC)(NC(=O)O2)O

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