Product Name: Gemcitabine HydrochlorideRequest Gemcitabine Hydrochloride
Synonym:LY-188011; LY 188011; LY188011; Abbreviations: dFdC; dFdCyd; difluorodeoxycytidine hydrochloride; gemcitabine; US brand name: Gemzar ,
Gemcitabine Hydrochloride Chemical Structure
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Biological Activity Gemcitabine hydrochloride is the hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
IUPAC/Chemical name:4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride
Canonical SMILES: O=C1N=C(N)C=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F.[H]Cl
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