Product Name: BazedoxifeneRequest Bazedoxifene
Synonym: Bazedoxifene; TSE-424; TSE424; TSE 424. ,
Bazedoxifene Chemical Structure
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Biological Activity Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. In late 2013, Pfizer received approval for bazedoxifene as part of the combination drug DUAVEE in the prevention (not treatment) of postmenopausal osteoporosis. It is approved in the European Union (marketed in Italy and Spain), and is in the late phases of review by the United States' Food and Drug Administration (FDA). When approved, bazedoxifene is to be sold by Pfizer under the tradename Viviant in the US and Conbriza in the EU. Bazedoxifene's combination with conjugated estrogens, Aprela, is undergoing Phase III studies for the treatment of postmenopausal symptoms (including the prevention of postmenopausal osteoporosis/treatment of osteopenia). The drug is being investigated for possible use in dyspareunia (painful sexual intercourse). It is also being studied for possible treatment of breast cancer.
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