Product Name: AbirateroneRequest Abiraterone
Synonym:US trade name: Zytiga. Other chemical name: 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol, (3?)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, ,
Abiraterone Chemical Structure
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Biological ActivityAbiraterone is the active metabolite of abiraterone acetate, which is an orally active acetate ester of the steroidal compound abiraterone with antiandrogen activity. Abiraterone acetate was approved by the U.S. Food and Drug Administration (FDA) in April 2011. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.
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