Product Name: TX1-85-1

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CAT#: A-6105


TX1-85-1 Chemical Structure TX1-85-1 chemical structure

IUPAC/Chemical name: N-(5-(1-(4-(4-Acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-phenoxyphenyl)acrylamide

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Biological Activity
TX1-85-1 is ErbB3 inhibitor. TX2-121-1 may exert Her3-dependent pharmacology through an allosteric mechanismthereby disrupting interactions between Her3 and other proteins such as Her3 or cMet consistent with results presented here and distinct from conventional kinase inhibitors, which block catalytic function. Her3 (also known as ErbB3) belongs to the epidermal growth factor receptor tyrosine kinases and is well credentialed as an anti-cancer target but is thought to be 'undruggable' using ATP-competitive small molecules because it lacks appreciable kinase activity.
Technical Data
M.Wt:      580.693
Formula:     C32H36N8O3
CAS#: 1603845-32-4
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.