Product Name:

RDEA-119 (BAY-869766)

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CAT#: A-1036    

Chemical Structure

Price of RDEA-119

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Biological Activity

RDEA119 is an orally bioavailable potent (IC50 at low nM), selective MEK inhibitor with potential anti-cancer activity. RDEA119 specifically inhibits mitogen-activated protein kinase kinase 1 (MAP2K1 or MAPK/ERK kinase 1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

RDEA119 is in phase I/II clinical trials for the treatment of advanced cancer and for the treatment of inflammation.

Technical Data

M.Wt: 572.34
Formula: C19H20F3IN2O5S
Optical purity: 100% by chiral HPLC
Chemical Purity: >99% by HPLC
Storage Conditions : Room temperature, or -20ºC for 2 year.