99% by HPLC - Purity whole section PUT image in userfiles/ and Storage condition at bottom, ADD pricing to price3.xml in PRODUCTS folder> PLX-7904(> 99% by HPLC )|Supplier|Active Biochem

Product Name: PLX-7904

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CAT#: A-6064


PLX-7904 Chemical Structure PLX-7904 chemical structure

IUPAC/Chemical name: 5-(2-Cyclopropylpyrimidin-5-yl)-3-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluorobenzoyl]-1H-pyrrolo[2,3-b]pyridine

Price of PLX-7904

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Biological Activity
PLX-7904 is a potent and selective paradox-breaker RAF inhibitor. PLX-7904 is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells. Importantly, PLX-7904 inhibits ERK1/2 phosphorylation in mutant BRAF melanoma cells with acquired resistance to vemurafenib/PLX4720 that is mediated by a secondary mutation in NRAS. Consistent with ERK1/2 reactivation driving the re-acquisition of malignant properties, P PLX-7904 promoted apoptosis and inhibited entry into S phase and anchorage-independent growth in mutant N-RAS-mediated vemurafenib-resistant cells.
Technical Data
M.Wt:      512.54
Formula:     C24H22F2N6O3S
CAS#: 1393465-84-3
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.