Product Name: NMS-873

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CAT#: A-1308


NMS-873 Chemical Structure NMS-873 chemical structure

IUPAC/Chemical name: 3-(3-(cyclopentylthio)-5-(((2-methyl-4'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)oxy)methyl)-4H-1,2,4-triazol-4-yl)pyridine.

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Biological Activity
NMS-873 is a potent, allosteric and specific VCP inhibitor (also known as p97 inhibitor). NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death. The consistent pattern of cancer cell killing by covalent and allosteric inhibitors provided critical validation of VCP as a cancer target.
Technical Data
M.Wt:      520.67
Formula:     C27H28N4O3S2
CAS#: 1418013-75-8
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.