Product Name: MLN-1117

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CAT#: A-6082


MLN-1117 Chemical Structure MLN-1117 chemical structure

IUPAC/Chemical name: [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-methanone

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Biological Activity
Serabelisib (also known as MLN1117, INK1117, and TAK-117) is an orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha isoform with potential antineoplastic activity. PI3K alpha inhibitor INK1117 selectively inhibits PI3K alpha kinase, including mutations of PIK3CA, in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K alpha-expressing tumor cells. By specifically targeting class I PI3K alpha, this agent may be more efficacious and less toxic than pan-PI3K inhibitors.
Technical Data
M.Wt:      363.377
Formula:     C19H17N5O3
CAS#: 1268454-23-4
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.