Product Name: MK-4827 HCl (Niraparib)

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CAT#: A-6032


MK-4827-HCL Chemical Structure MK-4827-HCL chemical structure

IUPAC/Chemical name: CHEMFIELD

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Biological Activity
MK-4827 (Niraparib) is an inhibitor of PARP 1 and 2 with IC50 = 3.8 and 2.1 nM, respectively, currently in clinical trials. In a whole cell assay, it inhibited PARP activity with EC50 = 4 nM and inhibited proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. MK-4827 was well tolerated in vivo and demonstrated efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.
Technical Data
M.Wt:      356.85
Formula:     C19H20N4O HCl
CAS#: 1038915-64-8
Purity: >99 % by HPLC, Chiral purity100%
Storage Conditions: Room temperature for short term or -20ºC for 2 years.