Product Name: MGCD-265
 CAT#: A-1973

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 Synonym:MGCD-265,MGCD265 ,

MGCD-265 Chemical Structure
MGCD-265chemical structure

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IUPAC/Chemical name:

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Biological Activity
MGCD265 is a multitargeted tyrosine kinase inhibitor, which is also a n orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor MGCD265 binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). Inhibition of these RTKs and their downstream signaling pathways may result in the inhibition of tumor angiogenesis and tumor cell proliferation in tumors overexpressing these RTKs. Check for active clinical trials or closed clinical trials using this agent.
Technical Data

Purity: >99%
Chemical Formula:C26H20FN5O2S2
Molecular Weight:517.6

IUPAC/Chemical name:N-((3-fluoro-4-((2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)carbamothioyl)-2-phenylacetamide
Canonical SMILES:O=C(NC(NC1=CC=C(OC2=C3C(C=C(C4=CN(C)C=N4)S3)=NC=C2)C(F)=C1)=S)CC5=CC=CC=C5

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