Product Name: LY-294002

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CAT#: A-6111


  Synonym:LY-294002,

LY-294002 Chemical Structure LY-294002 chemical structure


IUPAC/Chemical name: 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one


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Biological Activity
LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.
Technical Data
M.Wt:      307.34
Formula:     C19H17NO3
CAS#: 154447-36-6
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.

Reference