Product Name: KPT-8602

Request KPT-8602

CAT#: A-6035

  Synonym:KPT-8602, KPT8602

KPT-8602 Chemical Structure KPT-8602 chemical structure

IUPAC/Chemical name: CHEMFIELD

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Biological Activity
KPT-8602 is an orally bioavailable inhibitor of exportin-1 (XPO1; chromosome region maintenance 1 protein homolog; CRM1), with potential antineoplastic activity. Upon administration, XPO1 inhibitor KPT-8602 binds to the XPO1 cargo binding site, which prevents the XPO1-mediated nuclear export of cargo proteins such as tumor suppressor proteins (TSPs), including p53, p73, BRCA1/2, pRB, FOXO, and other growth regulatory proteins and leads to their selective accumulation in the nuclei of tumor cells. As a selective inhibitor of nuclear export (SINE), KPT-8602 restores the nuclear localization and function of tumor suppressing proteins which leads to the induction of apoptosis in tumor cells. XPO1, the major export factor that transports proteins from the nucleus to the cytoplasm, is overexpressed in a variety of cancer cell types while minimally expressed in normal, healthy cells. The export of tumor suppressor proteins into the cytoplasm prevents them from initiating apoptosis and leads to uncontrolled tumor cell proliferation.
Technical Data
M.Wt:      428.30
Formula:     C17H10F6N6O
CAS#: 1642300-52-4
Purity: >99 % by HPLC
Storage Conditions: Room temperature for short term or -20ºC for 3 years.