INC-280 Chemical Structure
2-fluoro- N-methyl- 4-(7- (quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin- 2-
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Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor INC280 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.
>99% by HPLC
2ºC to 8 ºC for short term, or -20ºC for 3 years.