Product Name: GSK-2141795( Uprosertib, GSK-795)
GSK-2141795 Chemical Structure
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GSK-2141795 is an orally bioavailable and selective Akt inhibitor which inhibits Akt 1, 2, 3, and Akt 1 E17K mutation at IC50 as 0.066 nM, 2 nM, 1.4 nM, 1.5 nM, and 0.2nM, respectively.
GSK-2141795 is an orally bioavailable AKT inhibitor. GSK-2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.
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