Product Name: GS-9901

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CAT#: A-6087

  Synonym:GS-9901 ,

GS-9901 Chemical Structure GS-9901  chemical structure

IUPAC/Chemical name: (S)-2,4-diamino-6-(((5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile

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Biological Activity
GS-9901 is a potent, orally active and highly selective inhibitor of PI3Kδ (PI3Kdelta IC50 = 1.0nM, HWB delta EC50 = 1.5 nM; CLpr hHep = 0.05 L/h/kg.). GS-9901 displays an excellent pharmacokinetic profile and is efficacious in a rodent model of rheumatoid arthritis. GS-9901 demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans. The favorable in vitro and in vivo attributes of GS-9901 resulted in its selection as a development candidate.
Technical Data
M.Wt:      477.8884
Formula:     C22H17ClFN9O
CAS#: 1640247-87-5
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.