Product Name: FGF-401

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CAT#: A-6073


FGF-401 Chemical Structure FGF-401 chemical structure

IUPAC/Chemical name: N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

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Biological Activity
FGF-401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, FGF-401 binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival.
Technical Data
M.Wt:      506.567
Formula:     C25H30N8O4
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.