Product Name: CPI-444

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CAT#: A-6099


CPI-444 Chemical Structure CPI-444 chemical structure

IUPAC/Chemical name: 1-(2-fluorobenzyl)-4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

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Biological Activity
CPI-444, also known as V81444, is an orally administered antagonist of the adenosine A2A receptor. Upon oral administration, CPI-444 binds to adenosine A2A receptors expressed on the surface of immune cells, including T-lymphocytes, natural killer (NK) cells, macrophages and dendritic cells (DCs). This prevents tumor-released adenosine from interacting with the A2A receptors on these key immune surveillance cells, thereby abrogating adenosine-induced immunosuppression in the tumor microenvironment.
Technical Data
M.Wt:      309.3044
Formula:     C16H12FN5O
CAS#: 443103-97-7
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.