Product Name: CNX-1351
 CAT#: A-1337

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CNX-1351 Chemical Structure
CNX-1351 chemical structure

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Biological Activity
CNX-1351 is an orally active selective inhibitor of PKB/Akt, a key enzyme in the PI3K/PKB/mTOR tumour cell survival pathway, and dysregulation of this pathway leads to tumour resistance to a number of important anti-cancer drugs.
Technical Data

Mol. Formula: C30H35N7O3S
MW: 573.71
CAS#: 1276105-89-5
Purity: >99%
CNX-1351 MSDS CNX-1351 CoA


CNX-1351 is a selective covalent Inhibitor of PI3Kα. CNX-1351 was tested against all four of the class I PI3K enzymes α, β, γ, and δ. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20−400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.

Purchase(buy) inhibitor CNX-1351 at Active Biochem and the United State(U.S.), Germany, Japan, France,United Kingdom(UK),Switzerland, Australia distributors.