Product Name: CCT-251921

Request CCT-251921

CAT#: A-6003


CCT-251921 Chemical Structure CCT-251921 chemical structure

IUPAC/Chemical name: 8-(2-Amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

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Biological Activity
CCT251921 is a potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. (IC50 data: CDK8:=2.3 nM; CDK19 = 2.6 nM). CCT251921 showed the optimal compromise of in vitro biochemical, pharmacokinetic, and physicochemical properties and is suitable for progression to animal models of cancer. The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.
Technical Data
M.Wt:      410.9
Formula:     C21H23ClN6O
Storage Conditions: 0ºC to 4 º for short term or -20ºC for 3 years.