CCT-251921 Chemical Structure
Price of CCT-251921
We offer a substantial discount on larger orders,
please inquire via firstname.lastname@example.org or Fax: 1-201-884-1288 (USA Fax#)
CCT251921 is a potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. (IC50 data: CDK8:=2.3 nM; CDK19 = 2.6 nM). CCT251921 showed the optimal compromise of in vitro biochemical, pharmacokinetic, and physicochemical properties and is suitable for progression to animal models of cancer. The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.
0ºC to 4 º for short term or -20ºC for 3 years.