Product Name: CB-1158

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CAT#: A-6098


CB-1158 Chemical Structure CB-1158 chemical structure

IUPAC/Chemical name: 2-amino-6-borono-2-(1-(2,4-dichlorobenzyl)piperidin-4-yl)hexanoic acid

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Biological Activity
CB-1158, also known as INCB01158, is a potent arginase inhibitor. CB-1158 has the potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role. CB-1158 may also have the ability to combine with other immuno-oncology therapies that target T-cell activation, such as CTLA-4 and PD-1 antibodies.
Technical Data
M.Wt:      417.134
Formula:     C18H27BCl2N2O4
CAS#: 1345810-21-0
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.