Product Name: BMS-911543
 CAT#: A-1175

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BMS-911543 Chemical Structure
BMS-911543 chemical structure

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IUPAC/Chemical name: BMS-911543,N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

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Biological Activity
BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS-911543 selectively inhibits JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.
Technical Data

M.Wt:      432.53
Formula:     C23H28N8O
CAS#: 1271022-90-2
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 2 years.
BMS-911543 MSDS BMS-911543 CoA

Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2
We report the characterization of BMS-911543, a potent and selective small-molecule inhibitor of the Janus kinase (JAK) family member, JAK2. Functionally, BMS-911543 displayed potent anti-proliferative and pharmacodynamic (PD) effects in cell lines dependent upon JAK2 signaling, and had little activity in cell types dependent upon other pathways, such as JAK1 and JAK3. BMS-911543 also displayed anti-proliferative responses in colony growth assays using primary progenitor cells isolated from patients with JAK2V617F-positive myeloproliferative neoplasms (MPNs).

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