Product Name: BGB-290

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CAT#: A-6108


BGB-290 Chemical Structure
BGB-290 chemical structure

IUPAC/Chemical name: (R)-2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one

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Biological Activity
BGB-290 is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.
Technical Data
M.Wt:      298.3214
Formula:     C16H15FN4O
CAS#: 1446261-44-1
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.