Product Name: BAY-1251152

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CAT#: A-6085


BAY-1251152 Chemical Structure BAY-1251152 chemical structure

IUPAC/Chemical name:

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Biological Activity
BAY-1251152 is a potent inhibitor of CDK9 and PTEF-b with potential antineoplastic activity. Upon administration, BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation. The protein complex PTEF-b, a heterodimer consisting of CDK9 and a regulatory cyclin subunit of the T family, is over-activated in various tumor cell types; it plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.
Technical Data
Purity: > 99% by HPLC
Storage Conditions: Room temperature for months, or -20ºC for 3 years.