BAY-1125976 Chemical Structure
Price of BAY-1125976
We offer a substantial discount on larger orders,
please inquire via firstname.lastname@example.org or Fax: 1-201-884-1288 (USA Fax#)
An orally bioavailable inhibitor of the serine/threonine protein kinase AKT (protein kinase B) isoforms 1 and 2 (AKT1/2) with potential antineoplastic activity. AKT1/2 inhibitor BAY1125976 selectively binds to and inhibits the phosphorylation and activity of AKT1/2 in a non-ATP competitive manner, which may result in the inhibition of the phosphatidylinositol 3 (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway. This may lead to both the reduction of cell proliferation and the induction of cell apoptosis in AKT-overexpressing tumor cells. The AKT signaling pathway is often deregulated in cancer and is associated with tumor cell proliferation, survival and migration.
>99% by HPLC
0ºC to 4 ºC for short term or -20ºC for 3 years..