Product Name:  AZD-1208  Request
CAT#: A-1501    

Chemical Structure

Price of AZD-1208

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Biological Activity

AZD-1208: is a pan-PIM kinase inhibitor. AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies。
Technical Data

M.Wt: 379.48
Formula: C21H21N3O2S
Cas#: 1204144-28-4
Purity: >99%
Storage Conditions: 2ºC to 8 ºC, or -20ºC for 3 years.