Product Name: ARRY-520
ARRY-520 Chemical Structure
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ARRY-520 is a Kinesin Spindle Protein (KSP) inhibitor which has sub-nanomolar potency in both enzymatic and cellular assays and is anti-mitotic, leading to cancer cell death. In vivo, ARRY-520 caused marked tumor regression in preclinical models of human cancer at tolerated doses, often leading to durable responses. ARRY-520 is highly soluble and can be delivered intravenously without requiring enabling formulations.
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