AMG-232 (AMG 232) is an extremely potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC50 = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg), and is currently in clinical evaluations.
Mol. Formula: C28H35Cl2NO5 S
Chiral Purity: 100%
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