Product Name: ABBV-075

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CAT#: A-6007


ABBV-075 Chemical Structure ABBV-075 chemical structure

IUPAC/Chemical name: N-[4-(2,4-difluorophenoxy)-3-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-Ethanesulfonamide

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Biological Activity
ABBV-075 is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine binding site in the BRD of certain BRD-containing protein(s), thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling, prevents the expression of certain growth-promoting genes, and leads to an inhibition of cell growth in susceptible tumors.
Technical Data
M.Wt:      459.47
Formula:     C22H19F2N3O4S
Purity: >99% by HPLC
CAS#: 1445993-26-9
Storage Conditions: 0ºC to 4 ºC for short term or -20ºC for 3 years.